Publications

Prevalence of detectable HIV-DNA and HIV-RNA in cerebrospinal fluid of youth with perinatal HIV and impaired cognition on antiretroviral therapy
View: AIDS
Children with perinatally acquired HIV exhibit distinct immune responses to 4CMenB vaccine
View: JCI Insight
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a
View: Cell
“Block and lock” viral integration sites in persons with drug-free control of HIV-1 infection
View: Current Opinion in HIV and AIDS
The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers
View: Journal of Clinical Investigation
Proliferation of HIV-1 reservoir cells: The delusion of infinite growth
View: Journal of Experimental Medicine
A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions
View: bioRxiv
Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure
Armani-Tourret M, Bone B, Tan TS, Sun W, Bellefroid M, Struyve T, Louella M, Yu XG, Lichterfeld M. Immune targeting of HIV-1 reservoir cells: a ...
View: Nature Reviews Microbiology
More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure
Fonseca JA, King AC, Chahroudi A. More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure. Curr HIV/AIDS Rep. ...
View: Current HIV/AIDS Reports
CD4+ T cells with latent HIV-1 have reduced proliferative responses to T cell receptor stimulation
Kufera JT, Armstrong C, Wu F, Singhal A, Zhang H, Lai J, Wilkins HN, Simonetti FR, Siliciano JD, Siliciano RF. CD4+ T cells with latent ...
View: Journal of Experimental Medicine
Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C
Buchholtz NVEJ, Nühn MM, de Jong TCM, Stienstra TAT, Reddy K, Ndung’u T, Ndhlovu ZM, Fisher K, Palmer S, Wensing AMJ, Symons J, Nijhuis M. ...
View: Virology Journal
Age at ART initiation and proviral reservoir size in perinatal HIV-1 infection: considerations for ART-free remission
Bekka S, Kelly K, Haaren M, Dhummakupt A, Persaud D. Age at ART initiation and proviral reservoir size in perinatal HIV-1 infection: considerations for ART-free ...
View: Current Opinion in HIV and AIDS
Viral and host mediators of non-suppressible HIV-1 viremia
Mohammadi, A., Etemad, B., Zhang, X. et al. Viral and host mediators of non-suppressible HIV-1 viremia. Nat Med 29, 3212–3223 (2023). https://doi.org/10.1038/s41591-023-02611-1
View: Nature Medicine
Role of Early Life Cytotoxic T Lymphocyte and Natural Killer Cell Immunity in Paediatric HIV Cure/Remission in the Anti-Retroviral Therapy Era
Vieira VA, Herbert N, Cromhout G, Adland E, Goulder P. Role of Early Life Cytotoxic T Lymphocyte and Natural Killer Cell Immunity in Paediatric HIV ...
View: Frontiers in Immunology
Proviral location affects cognate peptide-induced virus production and immune recognition of HIV-1-infected T cell clones
Dragoni F, Kwaa AK, Traut CC, Veenhuis RT, Woldemeskel BA, Camilo-Contreras A, Raymond HE, Dykema AG, Scully EP, Rosecrans AM, Smith KN, Bushman FD, Simonetti ...
View: Journal of Clinical Investigation
Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy
Lian X, Seiger KW, Parsons EM, Gao C, Sun W, Gladkov GT, Roseto IC, Einkauf KB, Osborn MR, Chevalier JM, Jiang C, Blackmer J, Carrington ...
View: Cell Host & Microbe
Phenotypic signatures of immune selection in HIV-1 reservoir cells
Sun, W., Gao, C., Hartana, C.A. et al. Phenotypic signatures of immune selection in HIV-1 reservoir cells. Nature 614, 309–317 (2023). https://doi.org/10.1038/s41586-022-05538-8
View: Nature
Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy
Sun W, Rassadkina Y, Gao C, Collens SI, Lian X, Solomon IH, Mukerji SS, Yu XG, Lichterfeld M. Persistence of intact HIV-1 proviruses in the ...
View: eLife
Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity
Morrocchi E, Pighi C, Pascucci GR, Cotugno N, Medri C, Amodio D, Colagrossi L, Ruggiero A, Manno EC, Casamento Tumeo C, Bernardi S, Smolen KK, ...
View: Clinical Infectious Diseases
An ordeal that does not heal: understanding barriers to a cure for HIV-1 infection
Lichterfeld M, Gao C, Yu XG. An ordeal that does not heal: understanding barriers to a cure for HIV-1 infection. Trends Immunol. 2022 Aug;43(8):608-616. doi: ...
View: Trends in Immunology
Longitudinal analysis of innate immune system in infants with perinatal HIV infection until 18 months of age
Dinh V, de Armas LR, Pallikkuth S, Pahwa R, Rinaldi S, Dang C, Kizhner A, Cotugno N, Palma P, Ismael N, Vaz P, Lain MG, ...
View: bioRxiv
Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure
Wu F, Simonetti FR. Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure. Curr HIV/AIDS Rep. 2023 Dec;20(6):428-439. doi: 10.1007/s11904-023-00674-w. Epub ...
View: Current HIV/AIDS Reports
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
McMyn NF, Varriale J, Fray EJ, Zitzmann C, MacLeod H, Lai J, Singhal A, Moskovljevic M, Garcia MA, Lopez BM, Hariharan V, Rhodehouse K, Lynn ...
View: Journal of Clinical Investigation
Last in first out: SIV proviruses seeded later in infection are harbored in short-lived CD4(+) T cells
Sambaturu N, Fray EJ, Wu F, Zitzmann C, Simonetti FR, Barouch DH, Siliciano JD, Siliciano RF, Ribeiro RM, Perelson AS, Molina-París C, Leitner T. Last ...
View: bioRxiv
Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV disease and posttreatment control in children
Herbert NG, Goulder PJR. Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV disease and posttreatment control in children. Curr ...
View: Current Opinion in HIV and AIDS
Immune Modulation of HIV-1 Reservoir Size in Early-Treated Neonates
Hartana CA, Broncano PG, Maswabi K, Ajibola G, Moyo S, Mohammed T, Maphorisa C, Makhema J, Powis KM, Lockman S, Burbelo PD, Gao C, Yu ...
View: Journal of Infectious Diseases
Immune correlates of HIV-1 reservoir cell decline in early-treated infants
Hartana CA, Garcia-Broncano P, Rassadkina Y, Lian X, Jiang C, Einkauf KB, Maswabi K, Ajibola G, Moyo S, Mohammed T, Maphorisa C, Makhema J, Yuki ...
View: Cell Reports
Immune activation and exhaustion marker expression on T-cell subsets in ART-treated adolescents and young adults with perinatal HIV-1 infection as correlates of viral persistence
Huang Y, Dhummakupt A, Khetan P, Nilles T, Zhou W, Mudvari P, Szewczyk J, Chen YH, Boritz E, Ji H, Agwu A, Persaud D. Immune ...
View: Frontiers in Immunology
IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in HIV-1 elite controllers
Hartana CA, Lancien M, Gao C, Rassadkina Y, Lichterfeld M, Yu XG. IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in HIV-1 elite ...
View: Cell Reports
How CD4+ T Cells Transcriptional Profile Is Affected by Culture Conditions: Towards the Design of Optimal In Vitro HIV Reactivation Assays
Pascucci GR, Morrocchi E, Pighi C, Rotili A, Neri A, Medri C, Olivieri G, Sanna M, Rasi G, Persaud D, Chahroudi A, Lichterfeld M, Nastouli ...
View: Biomedicines
HIV-1 reservoir size after neonatal antiretroviral therapy and the potential to evaluate antiretroviral-therapy-free remission (IMPAACT P1115): a phase 1/2 proof-of-concept study
Persaud D, Bryson Y, Nelson BS, Tierney C, Cotton MF, Coletti A, Jao J, Spector SA, Mirochnick M, Capparelli EV, Costello D, Szewczyk J, Nicodimus ...
View: Lancet HIV
HIV-1 reservoir evolution in Clade C infected infants from Mozambique
Koofhethile CK, Rinaldi S, Rassadkina Y, Dinh VB, Gao C, Pallikkuth S, Garcia-Broncano P, de Armas LR, Pahwa R, Cotugno N, Vaz P, Lain MG, ...
View: International Journal of Infectious Diseases
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control
Fardoos R, Nyquist SK, Asowata OE, Kazer SW, Singh A, Ngoepe A, Giandhari J, Mthabela N, Ramjit D, Singh S, Karim F, Buus S, Anderson ...
View: Frontiers in Immunology
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
White JA, Wu F, Yasin S, Moskovljevic M, Varriale J, Dragoni F, Camilo-Contreras A, Duan J, Zheng MY, Tadzong NF, Patel HB, Quiambao JMC, Rhodehouse ...
View: Journal of Clinical Investigation
Challenges and Opportunities of Therapies Targeting Early Life Immunity for Pediatric HIV Cure
Berendam SJ, Nelson AN, Yagnik B, Goswami R, Styles TM, Neja MA, Phan CT, Dankwa S, Byrd AU, Garrido C, Amara RR, Chahroudi A, Permar ...
View: Frontiers in Immunology
Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana
Shapiro RL, Ajibola G, Maswabi K, Hughes M, Nelson BS, Niesar A, Pretorius Holme M, Powis KM, Sakoi M, Batlang O, Moyo S, Mohammed T, ...
View: Science Translational Medicine
Broadly neutralizing antibodies: “The next thing” to treat children with HIV?
Mavigner M, Chahroudi A. Broadly neutralizing antibodies: “The next thing” to treat children with HIV? Sci Transl Med. 2023 Jul 5;15(703):eadi0293. doi: 10.1126/scitranslmed.adi0293. Epub 2023 ...
View: Science Translational Medicine
Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays
Khetan P, Liu Y, Dhummakupt A, Persaud D. Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays. Viruses. 2022 Nov 23;14(12):2608. doi: 10.3390/v14122608. PMID: 36560612; ...
View: Viruses
HIV-1 remission and possible cure in a woman after haplo-cord blood transplant
Hsu J, Van Besien K, Glesby MJ, Pahwa S, Coletti A, Warshaw MG, Petz L, Moore TB, Chen YH, Pallikkuth S, Dhummakupt A, Cortado R, ...
View: Cell
Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants
Bricker KM, Obregon-Perko V, Williams B, Oliver D, Uddin F, Neja M, et al. Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque ...
View: Journal of Virology
Distinct Molecular Signatures of Aging in Healthy and HIV-Infected Individuals
Rinaldi S, Pallikkuth S, De Armas L, et al. Distinct Molecular Signatures of Aging in Healthy and HIV-Infected Individuals. Journal of Acquired Immune Deficiency Syndromes ...
View: Journal of Acquired Immune Deficiency Syndromes
Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART
Obregon-Perko V, Bricker KM, Mensah G, Uddin F, Rotolo L, Vanover D, et al. Dynamics and origin of rebound viremia in SHIV-infected infant macaques following ...
View: JCI Insight
Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure
Amin O, Powers J, Bricker KM, Chahroudi A. Understanding Viral and Immune Interplay During Vertical Transmission of HIV: Implications for Cure. Front Immunol. 2021;12:757400. Epub ...
View: Frontiers in Immunology